Vitamin B6 (as P5P)
Vitamin B6, or pyridoxine, is a water‑soluble molecule that metabolizes into cofactors for more than 100 enzymes in the human body. Vitamin B6 transforms in the body into an active coenzyme pyridoxal 5‑phosphate (P5P), which is also commonly known as PLP. P5P is an essential molecule for the production of GABA, serotonin, and the conversion to melatonin. It may also help support the production of certain neurotransmitters to help promote cognitive function and brain health.
Tyrosine
The amino acid tyrosine is a critical building block of catecholamines such as dopamine and norepinephrine. Conditions related to chronic stress can influence catecholamine levels in the body, which may have deleterious downstream effects including increased oxidative stress and changes to glucose metabolism. Research indicates that supplementation with tyrosine may help increase levels of dopamine and norepinephrine in the brain. It may also help attenuate neurotransmitter depletion in actively firing neurons. Tyrosine may therefore help prevent cognitive changes associated with decreased catecholamine levels and may support brain health in individuals exposed to chronic stress.
Taurine
Taurine is a sulfur‑containing amino acid that is particularly abundant in the brain and in cardiac and skeletal muscle. It can be made endogenously from cysteine; however, stress and certain pathologies may limit the body’s ability to synthesize taurine. Taurine has many physiological actions in the body including supporting mitochondrial function, cellular calcium levels, and membrane stability. It has also been shown to support antioxidative status
5‑hydroxytryptophan (5‑HTP)
5‑HTP is a precursor to the biosynthesis of the neurotransmitter serotonin. Synthesis of serotonin in the human body starts with the conversion of the essential amino acid L‑tryptophan to 5‑HTP, which is then transformed into serotonin. 5‑HTP has the ability to cross the blood‑brain barrier (BBB) and convert to serotonin without feedback inhibition.
gamma‑Aminobutyric acid (GABA)
GABA is a non‑protein amino acid and acts as the primary inhibitory neurotransmitter in the brain and central nervous system. It is synthesized by P5P and is also produced by certain bacteria in the gut microbiome.
L‑glutamine
the most abundant amino acid in the body and plays critical roles in human health. It acts as an intermediary in energy metabolism and is a substrate for the synthesis of glutathione, neurotransmitters, and nucleotide bases. While glutamine is classically described as a non‑essential amino acid, recent observations suggest it may be “conditionally essential” during illness and other times of stress on the body
Inositol
a molecule found in most vegetable and animal cells and is closely related to B vitamins. It is a precursor to second messengers for many signaling pathways and is critical for signal transduction in many organs including the brain, reproductive organs, and kidneys. Its derivatives have been shown to support the structure and proliferation of cells.
