Biopure C3 (60 ct)

Biopure C3 is a patent pending, highly bioavailable curcuminoid formulation. This product contains a unique combination of three bioactive, health-promoting curcuminoids: curcumin, bisdemethoxy curcumin and demethoxy curcumin, along with turmeric oil. The three curcuminoids are the strongest, most protective and best researched constituents of the turmeric root. Naturally occurring turmeric root powder contains only 5-7% curcumin, while the blend in our formula is concentrated to contain 95% curcuminoids, of which curcumin represents 70%.

The crystalline structure of curcumin renders it difficult to absorb in the GI tract. According to researchers, “The potential health benefits of curcumin are limited by its poor solubility, low absorption from the gut, rapid metabolism and rapid systemic elimination.”1 For this reason, Biopure C3 is manufactured using a new process, which is an all-natural formulation that improves the absorption and delivery of curcumin. This process uses a proprietary blend of turmeric oil, sunflower lecithin, and vitamin E, without the use of potentially harmful surfactants.

This delivery technology increases the absorption rate and reduces the absorption time for nutrients and may allow for superior effects through lower dosages. Curcum-Evail® is unique in that it has been shown to increase tetrahydrocurcumin as well as curcumin, demethoxycurcumin and bisdemethoxycurcumin in plasma. Tetrahydrocurcumin is a major metabolite of curcumin and demonstrates remarkable antioxidant properties exceeding those of curcumin alone.2-4

Compared to reference products containing equal concentrations of curcuminoids, Biopure C3 exhibited several-fold higher absorption, resulting in plasma levels of tetrahydrocurcumin that were nearly 30 times higher. Area under the curve (AUC) amounts for plasma levels of all three curcuminoids in this formula were significantly higher than for the reference products.

BENEFITS SHOWN IN RESEARCH USING CURCUMIN EXTRACTS:

IMMUNE SYSTEM REGULATION

Inflammation – injury, postoperative, joint wear and tear (osteoarthritis)

Allergic reactions – asthma

Autoimmune activity reduction – rheumatoid arthritis and multiple sclerosis in animals

NK cell activity increase

Anti-cancer properties – breast, prostate, colon, pancreatic, glioma, ovarian

ANTIMICROBIAL • Antiviral, Epstein Barr and HIV virus

Antibacterial, antiparasitic

GI PROTECTION & HEALING

Stomach ulcer, Crohn's or proctitis9

CARDIOVASCULAR PROTECTION

Reduces cholesterol oxidation and levels, increases HDL

Reduces fibrinogen

Reduces platelet aggregation

BRAIN PROTECTION

Reduces brain damage following ischemia (reduced blood flow)

Reduces development and regression of Alzheimer's disease progression in animal models

Reduces gliomas (brain tumors)

Antidepressant effects

LIVER PROTECTION from alcohol and aflatoxin (peanut fungus)

TOXIC METAL CHELATOR

Effective chelator of copper and iron

ANTIOXIDANT

BILE SUPPORT

Enhances bile flow and solubility

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

References

1. Jäger R, Lowery RP, Calvanese AV, Joy JM, Purpura M, Wilson JM. Comparative absorption of curcumin formulations. Nutrition Journal. 2014;13:11.

2. Osawa T, Sugiyama Y, Inayoshi M, Kawakishi S. Antioxidative activity of tetrahydrocurcuminoids. Biosci Biotechnol Biochem. 1995 Sep;59(9):1609-12.

3. Lai CS, Wu JC, Yu SF, Badmaev V, Nagabhushanam K, Ho CT, Pan MH. Tetrahydrocurcumin is more effective than curcumin in preventing azoxymethane-induced colon carcinogenesis. Mol Nutr Food Res. 2011 Dec;55(12):1819-28.

4. Okada K, Wangpoengtrakul C, Tanaka T, Toyokuni S, Uchida K, Osawa T. Curcumin and especially tetrahydrocurcumin ameliorate oxidative stress-induced renal injury in mice. J Nutr. 2001 Aug;131(8):2090-5.

5. Araujo CC, Leon LL.Biological activities of Curcuma longa L. Mem Inst Oswaldo Cruz. 2001 Jul;96(5):723-8.

6. Yadav VS, Mishra KP, Immunomodulatory effects of curcumin. Immunopharmacol Immunotoxicol. 2005;27(3):485-97.

7. Takada Y, Bhardwaj A. Nonsteroidal anti-inflammatory agents differ in their ability to suppress NF-kappaB activation, inhibition of expression of cyclooxygenase-2 and cyclin D1, and abrogation of tumor cell proliferation. Oncogene. 2004 Dec 9;23(57):9247-58.

8. Swarnakar S, Ganguly K.Curcumin regulates expression and activity of matrix metalloproteinases 9 and 2 during prevention and healing of indomethacin-induced gastric ulcer. J Biol Chem. 2005 Mar 11;280(10):9409-15. Epub 2004 Dec 22.

9. Suzuki M, Nakamura T. Elucidation of anti-allergic activities of curcumin-related compounds with a special reference to their anti-oxidative activities. Biol Pharm Bull. 2005 Aug;28(8):1438-43.

10. Kobayashi T, Hashimoto S Curcumin inhibition of Dermatophagoides farinea-induced interleukin-5 (IL-5) and granulocyte macrophage-colony stimulating factor (GM-CSF) production by lymphocytes from bronchial asthmatics. Biochem Pharmacol. 1997 Oct 1;54(7):819-24.

11. Yamamoto H, Hanada K. Inhibitory effect on curcumin on mammalian phospholipase D activity. FEBS Lett. 1997 Nov 10;417(2):196-8.

12. Chainani-Wu N. Safety and anti-inflammatory activity of curcumin: a component of tumeric (Curcuma longa). J Altern Complement Med. 2003 Feb;9(1):161-8.

13. Holt PR, Katz S Curcumin therapy in inflammatory bowel disease: a pilot study. Dig Dis Sci. 2005 Nov;50(11):2191-3.

14. Heck AM, et al. Potential interactions between alternative therapies and warfarin. Am J Health Syst Pharm. Jul2000;57(13):1221-7.

15. Reddy AC, et al. Effect of Dietary Turmeric (Curcuma longa) on Iron-induced Lipid Peroxidation in the Rat Liver. Food Chem Toxicol. Mar1994;32(3):279-83.

16. Subramanian M, et al. Diminution of Singlet Oxygen-induced DNA Damage by Curcumin and Related Antioxidants. Mutat Res. Dec1994;311(2):249-55.

17. Ruby AJ, et al. Anti-tumour and Antioxidant Activity of Natural Curcuminoids. Cancer Lett. Jul1995;94(1):79-83.

18. Ammon HP, et al. Mechanism of Anti-inflammatory Actions of Curcumin and Boswellic Acids. J Ethnopharmacol. 1993;38:113.

19. Deodhar SD, et al. Preliminary Studies on Anti-Rheumatic Activity of Curcumin. Ind J Med Res. 1980;71:632.

20. Xu Y, Ku BS, The effects of curcumin on depressive-like behaviors in mice. Eur J Pharmacol. 2005 Jul 25;518(1):40-6.

21. Yang F, Lim GP. Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo. J Biol Chem. 2005 Feb 18;280(7):5892-901. Epub 2004 Dec 7.

22. Srivastava V, et al. Effect of Curcumin on Platelet Aggregation and Vascular Prostacyclin Synthesis. Arzneim Forsch/Drug Res. 1986;36:715-17.

23. Mehta K, et al. Antiproliferative Effect of Curcumin (Diferuloylmethane) against Human Breast Tumor Cell Line. Anticancer Drugs. Jun1997;8(5):470-81.

24. Rao CV, et al. Chemoprevention of Colon Carcinogenesis by Dietary Curcumin, a Naturally Occurring Plant Phenolic Compound. Cancer Res. Jan1995;55(2):259-66.

25. Ranjan D, et al. The Effect of Curcumin On Human B-Cell Immortalization by Epstein-Barr Virus. Am Surg. Jan1998;64(1):47-51.

26. Mazumder A, et al. Inhibition of Human Immunodefficiency Virus Type-I Integrase by Curcumin. Biochem. Pharmacol. 1995;49(11):1165-70.

27. Barthelemy S, et al. Curcumin and Curcumin Derivatives Inhibit Tat-mediated Transactivation of Type 1 Human Immunodeficiency Virus Long Terminal Repeat. Res Virol. Jan1998;149(1):43-52.

28. Kawamori T, et al. Chemopreventive Effect of Curcumin, A Naturally Occurring Anti-inflammatory Agent, During the Promotion/Progression Stages of Colon Cancer. Cancer Res. Feb1999;59(3):597-601.

29. Hidaka H, Ishiko T, Furuhashi T, Kamohara H, Suzuki S, Miyazaki M, et al. Curcumin inhibits interleukin 8 production and enhances interleukin 8 receptor expression on the cell surface:impact on human pancreatic carcinoma cell growth by autocrine regulation. Cancer. Sep2002;95(6):1206-14.

30. Soni KB, et al. Effect of Oral Curcumin Administration on Serum Peroxides and Cholesterol Levels in Human Volunteers. Indian J Physiol Pharmacol. Oct1992;36(4):273-75.

31. Sharma OP. Antioxidant Activity of Curcumin and Related Compounds. Biochem Pharmacol. 1976;46:1013.

32. Natarajan C, Bright JJ Curcumin inhibits experimental allergic encephalomyelitis by blocking IL-12 signaling through Janus kinase-STAT pathway in T lymphocytes. J Immunol. 2002 Jun 15;168(12):6506-1329.

33. Kim SY, Jung SH. Kim HS. Curcumin is a potent broad spectrum inhibitor of matrix metalloproteinase gene expression in human astroglioma cells. Biochem Biophys Res Commun. 2005 Nov 18;337(2):510-6. Epub 2005 Sep 21.

34. Danilenko M, Studzinski GP.. Enhancement by other compounds of the anti-cancer activity of vitamin D(3) and its analogs. Exp Cell Res. 2004 Aug 15;298(2):339-58.

35. Sharma RA, McLelland HR, Hill KA, et al. Pharmacodynamic and pharmacokinetic study of oral Curcuma extract in patients with colorectal cancer. Clin Cancer Res 2001;7:1894-900.

36. Zhang F, Altorki NK, Mestre JR, et al. Curcumin inhibits cyclooxygenase-2 transcription in bile acid- and phorbol ester-treated human gastrointestinal epithelial cells. Carcinogenesis 1999;20:445-51.

37. Surh YJ. Anti-tumor promoting potential of selected spice ingredients with antioxidative and anti-inflammatory activities: a short review. Food Chem Toxicol 2002;40:1091-7.

38. Miquel J, Bernd A, The curcuma antioxidants: pharmacological effects and prospects for future clinical use. A review. Arch Gerontol Geriatr. 2002 Feb;34(1):37-46.

39. Deeb D, Xu YX, Jiang H, et al. Curcumin (diferuloyl-methane) enhances tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in LNCaP prostate cancer cells. Mol Cancer Ther 2003;2:95-103.

40. Thaloor D, Singh AK, Sidhu GS, et al. Inhibition of angiogenic differentiation of human umbilical vein endothelial cells by curcumin. Cell Growth Differ 1998;9:305-12.

41. Shah BH, Nawaz Z, Pertani SA. Inhibitory effect of curcumin, a food spice from turmeric, on platelet-activating factor- and arachidonic acid-mediated platelet aggregation through inhibition of thromboxane formation and Ca2+ signaling. Biochem Pharmacol 1999;58:1167-72.

42. Thamlikitkul V, Bunyapraphatsara N, Dechatiwongse T, et al. Randomized double blind study of Curcuma domestica Val. for dyspepsia. J Med Assoc Thai 1989;72:613-20.

43. Rasyid A, Rahman AR, Jaalam K, Lelo A. Effect of different curcumin dosages on human gall bladder. Asia Pac J Clin Nutr 2002;11:314-8.

44. Leu TH, Maa MC.The molecular mechanisms for the antitumorigenic effect of curcumin. Curr Med Chem Anti-Canc Agents. 2002 May;2(3):357-70.

45. Antony S, Kuttan R, Kuttan G. Immunomodulatory activity of curcumin. Immunol Invest 1999;28:291-303.

46. Kuttan R, Sudheeran PC, Josph CD. Turmeric and curcumin as topical agents in cancer therapy. Tumori 1987;73:29-31.

47. Thapliyal R, Maru GB. Inhibition of cytochrome P450 isozymes by curcumins in vitro and in vivo. Food Chem Toxicol. 2001 Jun;39(6):541-7.

48. Lal B, Kapoor AK, Asthana OP, et al. Efficacy of curcumin in the management of chronic anterior uveitis. Phytother Res 1999;13:318-22.

49. Takada Y, Bhardwaj A, Potdar P, Aggarwal BB. Nonsteroidal anti-inflammatory agents differ in their ability to suppress NF-kappaB activation, inhibition of expression of cyclooxy genase-2 and cyclin D1, and abrogation of tumor cell proliferation. Oncogene 2004 Oct 18.

50. Cole GM, Lim GP, Prevention of Alzheimer's disease: Omega-3 fatty acid and phenolic anti-oxidant interventions. Neurobiol Aging. 2005 Oct 30; [Epub ahead of print]

51. Wang Q, Sun AY, Neuroprotective mechanisms of curcumin against cerebral ischemia-induced neuronal apoptosis and behavioral deficits. J Neurosci Res. 2005 Oct 1;82(1):138-48.

52. Chan MM, Fong D. Inhibition of growth and sensitization to cisplatin-mediated killing of ovarian cancer cells by polyphenolic chemopreventive agents. J Cell Physiol. 2003 Jan;194(1):63-70.

53. Zheng L, Tong Q. Growth-inhibitory effects of curcumin on ovary cancer cells and its mechanisms. J Huazhong Univ Sci Technolog Med Sci. 2004;24(1):55-8.

54. Rajakrishnan V, Viswanathan P Neuroprotective role of curcumin from curcuma longa on ethanol-induced brain damage. Phytother Res. 1999 Nov;13(7):571-4.

55. Rajakrishnan V, Jayadeep A. Changes in the prostaglandin levels in alcohol toxicity: effect of curcumin and N-acetylcysteine. J Nutr Biochem. 2000 Oct;11(10):509-14

56. Satoskar RR, Shah SJ. Evaluation of anti-inflammatory property of curcumin (diferuloyl methane) in patients with postoperative inflammation. Int J Clin Pharmacol Ther Toxicol.1986 Dec;24(12):651-4.

57. Baum L, Ng A. Curcumin interaction with copper and iron suggests one possible mechanism of action in Alzheimer's disease animal models. J Alzheimers Dis. 2004 Aug;6(4):367-77.

58. Rajakrishnan V, Jayadeep A. Changes in the prostaglandin levels in alcohol toxicity: effect of curcumin and N-acetylcysteine. J Nutr Biochem. 2000 Oct;11(10):509-14

59. Soni KB, Rajan A. Reversal of aflatoxin induced liver damage by turmeric and curcumin. Cancer Lett. 1992 Sep 30;66(2):115-21.

60. Schulze-Tanzil G. Effects of curcumin (diferuloylmethane) on nuclear factor kappaB signaling in interleukin-1beta-stimulated chondrocytes. Ann N Y Acad Sci. 2004 Dec;1030:578-86.